|
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Full sequencing of TMEM175/GAK/DGKQ followed by genotyping of specific associated variants was performed in PD (n = 1,575) and rapid eye movement sleep behavior disorder (RBD) patients (n = 533) and in controls (n = 1,583).
|
31658403 |
2020 |
|
REM Sleep Behavior Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Full sequencing of TMEM175/GAK/DGKQ followed by genotyping of specific associated variants was performed in PD (n = 1,575) and rapid eye movement sleep behavior disorder (RBD) patients (n = 533) and in controls (n = 1,583).
|
31658403 |
2020 |
|
Parkinsonian Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Although DNAJC6 (Auxilin), DNAJC12, and DNAJC5 (CSPα) exhibit strong genetic association with disease, DNAJC26 (GAK), DNAJC13 (RME-8), and DNAJC10 (Erdj5) require additional evidence to definitively link reported variants to parkinsonism.
|
31120186 |
2019 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
We demonstrated that the host kinases AAK1 and GAK regulate HCV infection by controlling these clathrin-associated APs.
|
29535204 |
2018 |
|
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We describe recent advances on roles of kinases TAOK2, TNIK and CDKL5 in neuronal development and the converging pathways of LRRK2, PINK1 and GAK in Parkinson's Disease.
|
29241837 |
2018 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
We previously reported that AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but the underlying mechanism and relevance to other viruses or in vivo infections remained unknown.
|
28240606 |
2017 |
|
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating, though its PD-related function remains elusive.
|
28147270 |
2017 |
|
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Together, these findings provide strong evidence for GAK clathrin-binding- and J-domain transcripts' influence on PD pathogenicity, and for a role for GAK in regulating synaptic function in PD.
|
27508417 |
2016 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used 2 PD case-control data sets (Washington University and the Parkinson's Progression Markers Initiative) to determine whether polymorphisms located at the GWAS top hits (GBA, ACMSD/TMEM163, STK39, MCCC1/LAMP3, GAK/TMEM175, SNCA, and MAPT) show association with AAO or motor progression.
|
26601739 |
2016 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
|
25653444 |
2015 |
|
Tremor
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Based on motor Unified Parkinson's Disease Rating Scale subscores, MAPT (P = .0002) and CCDC62 (P = .003) were predominantly associated with bradykinesia, and we further discovered associations between SREBF1 (rs11868035; P = .005) and gait impairment, SNCA (rs356220; P = .04) and rigidity, and GAK (rs1564282; P = .03) and tremor.
|
24514572 |
2014 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies identified PARK16 variants rs823128 and rs947211, PARK17/GAK rs11248051 and PARK18/HLA-DRA rs3129882 as risk factors for Parkinson's disease (PD).
|
24373818 |
2014 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results supported the association between the rs11248051 variant in GAK and PD risk in a Taiwanese population.
|
24039160 |
2013 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations.
|
23826309 |
2013 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients.
|
23618683 |
2013 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, AAK1 and GAK, serine/threonine kinases known to stimulate binding of AP2M1 to host cargo proteins, regulate core-AP2M1 binding and are essential for HCV assembly.
|
22916011 |
2012 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
Lymphocyte Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
|
22286170 |
2012 |
|
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Functional studies of GAK to unravel its role in the pathophysiologic pathway of PD will be useful.
|
22198721 |
2012 |
|
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.
|
21258085 |
2011 |
|
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These observations provide evidence that GAK is associated with PD risk and suggest that GAK and α-synuclein interact in a pathway involved in PD pathogenesis.
|
21258085 |
2011 |